Full text not available from this repository.Item Type:ArticleItem Status:Live ArchiveAbstractClinical signs of experimental autoimmune encephalomyelitis (EAE) are associated with the selective recruitment of CD4+ memory (CD45RB(low) CD44(high)) T cells into the central nervous system (CNS). However Replica Hermes Belt, we have found that many of these recently recruited memory cells are CD44(low), suggesting that the CD44 antigen may be involved in, and transiently lost during, the extravasation process. Indeed, administration of a CD44 specific antibody (IM7.8.1) induced leucocyte CD44 shedding and both prevented the development and ameliorated the severity of established EAE by inhibiting mononuclear cell infiltration into the CNS.
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